Cotaus Pipette Tips Manufactured with Strict Quality Control

At Cotaus, we understand that the accuracy and reliability of laboratory results depend on the precision of every tool used. That’s why our pipette tips are produced under the strictest quality control standards, ensuring they meet the highest performance benchmarks for accurate pipetting. From the selection of materials to the final inspection, every step of the production process is carefully monitored to guarantee consistency, durability, and precision. Let's see How we do.

1. Tips' volume accuracy and precision

Cotaus each batch of pipette tips undergoes volume calibration to ensure they fall within the standard tolerance range. Random samples are taken from each batch and multiple liquid aspirates and dispenses are performed to check the consistency of the tip’s volume accuracy and precision.

2. Tips' dimensional consistency

Random samples are taken from each batch to test the tip’s dimensions to ensure they conform to standard specifications(Uniformity of product dimension≤0.15), ensuring consistent inner and outer diameters, length and shape to prevent fit issues.

3. Tips' physical integrity

The tips are checked for cracks, air bubbles, or any physical defects that might affect their pipetting performance or lead to contamination.

Pressure and bend tested to ensure they can withstand normal operating pressure and bending without breaking or deforming.

4. Tips' airtight seal and fit

Verifying that the pipette tips fit securely onto pipettes or automatic liquid handling platform, ensuring no air leakage during aspiration or dispensing.
Ensure the tips are compatible with various pipette brands and robotic liquid handling systems, ensuring no loosening, slipping, or improper fit.

5. Tips' concentricity

Using precision instruments such as laser scanners or coordinate measuring machines (CMM), to check the roundness of both the inner and outer diameters. Cotaus pipette tips require concentricity errors within ±0.2 mm.

6. Tips' perpendicularity

Using specialized perpendicularity testing instruments to check the angle between the tip's bottom surface and its central axis. The error is typically required within a tolerance of 0.5 millimeters or less.

7. Tips' liquid retention and low-residue testing

Special surface treatments are applied to ensure the inner surface of the tip is smooth and reduces liquid retention, especially when handling viscous liquids.
Measurement of liquid residue left in the tip after aspiration and dispensing, particularly when handling small volumes, to ensure minimal liquid carryover.

8. Tips' retention force

Measuring the force required to attach and detach the pipette tips, ensuring they are neither too tight (difficult to remove) nor too loose (which could cause aspiration issues).

9. Tips' surface smoothness

Ensures that both the inside and outside surfaces of the tips are smooth, with no irregularities or roughness, testing for smooth internal and external surfaces to minimize sample retention, avoid contamination, and enhance the efficiency of liquid transfer.

10. Tips' sterility

Ensures that sterile tips are sealed properly during packaging to prevent contamination. Cotaus disposable tips utilize electron beam sterilization which is a safe and efficient method that leaves no chemical residue.

11. Tips' resistance and CV values

Resistance testing ensures the durability and performance of the pipette tip under different physical and chemical conditions.
CV testing evaluates the precision of liquid transfer by measuring the consistency of the tip’s performance, ensuring high accuracy and low variability.

12. Tips' material durability

Adopt imported medical-grade polypropylene (PP) materials to ensure the dimensional stability of the tips, Cotaus ensures consistency in the material used to avoid discrepancies in dimensions or performance that could affect pipette accuracy.

13. Tips' manufacture equipment

Cotaus owns 120+ automated manufacturing assembly lines, using high-precision injection molding machines to ensure dimensional consistency and accuracy of the tips, improving efficiency and reducing human error.

Cotaus owns a mold manufacturing company that produces high-precision molds for pipette tip production, ensuring accurate shape, size, concentricity, and perpendicularity.

Quality control equipment including precision balances and measuring devices, laser measurement instruments, automated inspection systems, etc.

14. Tips' production environment

Manufactured in a 100000-class dust-free workshop to avoid contamination from dust, particles, or contaminants.

15. Tips' QC Standards

Ensures the tips comply with quality standards (ISO13485, CE, FDA), guaranteeing their performance, precision, and reliability.

16. Tips' production process management

ERP Systems manage raw materials, production scheduling, inventory, and shipping, ensuring a smooth and timely production process. Critical production parameters and quality inspection data are recorded and stored during production, ensuring traceability for each batch of tips and facilitating post-production quality tracking.